RED CELLS Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression
نویسندگان
چکیده
1Department of Medicine, Mount Sinai School of Medicine, New York, NY; 2Department of Molecular, Cellular, and Developmental Biology, Mount Sinai School of Medicine, New York, NY; 3Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY; 4Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY; and 5Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY
منابع مشابه
Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression.
Primitive erythroblasts (EryPs) are the first hematopoietic cell type to form during mammalian embryogenesis and emerge within the blood islands of the yolk sac. Large, nucleated EryPs begin to circulate around midgestation, when connections between yolk sac and embryonic vasculature mature. Two to 3 days later, small cells of the definitive erythroid lineage (EryD) begin to differentiate withi...
متن کاملRED CELLS Enucleation of primitive erythroid cells generates a transient population of “pyrenocytes” in the mammalian fetus
Enucleation is the hallmark of erythropoiesis in mammals. Previously, we determined that yolk sac–derived primitive erythroblasts mature in the bloodstream and enucleate between embryonic day (E)14.5 and E16.5 of mouse gestation. While definitive erythroblasts enucleate by nuclear extrusion, generating reticulocytes and small, nucleated cells with a thin rim of cytoplasm (“pyrenocytes”), it is ...
متن کاملMaturation and enucleation of primitive erythroblasts during mouse
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متن کاملEnucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus.
Enucleation is the hallmark of erythropoiesis in mammals. Previously, we determined that yolk sac-derived primitive erythroblasts mature in the bloodstream and enucleate between embryonic day (E)14.5 and E16.5 of mouse gestation. While definitive erythroblasts enucleate by nuclear extrusion, generating reticulocytes and small, nucleated cells with a thin rim of cytoplasm ("pyrenocytes"), it is ...
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Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis. Defective terminal erythropoiesis contributes to decreased generation of RBCs in many disorders. Specifically, ineffective nuclear expulsion (enucleation) during terminal maturation is an obstacle to therapeutic RBC production in vitro. To obtain mechanistic insights into terminal erythropoiesis we focused ...
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